Transcobalamin II and the membrane receptor for the transcobalamin II-cobalamin complex.

@article{Rothenberg1995TranscobalaminIA,
  title={Transcobalamin II and the membrane receptor for the transcobalamin II-cobalamin complex.},
  author={Sheldon P. Rothenberg and Elizabeth Quadros},
  journal={Bailliere's clinical haematology},
  year={1995},
  volume={8 3},
  pages={499-514}
}
Transcobalamin II is a plasma protein that binds vitamin B12 (cobalamin) as it is absorbed in the terminal ileum and distributes it to tissues. The circulating transcobalamin II-cobalamin complex binds to receptors on the plasma membrane of tissue cells and is then internalized by receptor-mediated endocytosis. A number of genetic abnormalities are characterized either by a failure to express transcobalamin II or by synthesis of an abnormal protein. These disorders result in cellular cobalamin… CONTINUE READING

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