Transchromosomal mouse embryonic stem cell lines and chimeric mice that contain freely segregating segments of human chromosome 21.

@article{Hernndez1999TranschromosomalME,
  title={Transchromosomal mouse embryonic stem cell lines and chimeric mice that contain freely segregating segments of human chromosome 21.},
  author={D. Hern{\'a}ndez and Patrick J. Mee and Janice E Martin and Victor L. J. Tybulewicz and Elizabeth M. C. Fisher},
  journal={Human molecular genetics},
  year={1999},
  volume={8 5},
  pages={923-33}
}
At least 8% of all human conceptions have major chromosome abnormalities and the frequency of chromosomal syndromes in newborns is >0.5%. Despite these disorders making a large contribution to human morbidity and mortality, we have little understanding of their aetiology and little molecular data on the importance of gene dosage to mammalian cells. Trisomy 21, which results in Down syndrome (DS), is the most frequent aneuploidy in humans (1 in 600 live births, up to 1 in 150 pregnancies world… CONTINUE READING
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