Transcellular transport of domoic acid across intestinal Caco-2 cell monolayers.

  title={Transcellular transport of domoic acid across intestinal Caco-2 cell monolayers.},
  author={Osamu de Sandes Kimura and Yuichi Kotaki and Naoya Hamaue and Koichi Haraguchi and Tetsuya Endo},
  journal={Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association},
  volume={49 9},
The intestinal absorption mechanism of domoic acid (DA) was investigated using Caco-2 cells. DA is a tricarboxylic amino acid that contains a glutamic acid moiety, and causes deficits in short-term memory by binding to glutamate receptors as an agonist of glutamic acid. Caco-2 cell monolayers cultured on permeable membranes were incubated with 100 μM DA on either the apical or basolateral side, and the transcellular transport of DA was measured. The transcellular transport of DA from the apical… CONTINUE READING

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