Transcellular transport of creatinine in renal tubular epithelial cell line LLC-PK1.

@article{Urakami2005TranscellularTO,
  title={Transcellular transport of creatinine in renal tubular epithelial cell line LLC-PK1.},
  author={Yumiko Urakami and Naoko Kimura and Masahiro Okuda and Satohiro Masuda and Toshiya Katsura and Ken-ichi Inui},
  journal={Drug metabolism and pharmacokinetics},
  year={2005},
  volume={20 3},
  pages={
          200-5
        }
}
BACKGROUND/AIM Creatinine is excreted into urine via tubular secretion in addition to glomerular filtration. In the present study, characteristics of the creatinine transport in renal epithelial cells were investigated. METHODS The transcellular transport and accumulation of [14C]creatinine and [14C]tetraethylammonium (TEA) were assessed using LLC-PK1 cell monolayers cultured on porous membrane filters. RESULTS [14C]Creatinine was transported directionally from the basolateral to apical… CONTINUE READING

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