Transcellular transport of creatinine in renal tubular epithelial cell line LLC-PK1.

  title={Transcellular transport of creatinine in renal tubular epithelial cell line LLC-PK1.},
  author={Y. Urakami and Naoko Kimura and M. Okuda and S. Masuda and T. Katsura and K. Inui},
  journal={Drug metabolism and pharmacokinetics},
  volume={20 3},
  • Y. Urakami, Naoko Kimura, +3 authors K. Inui
  • Published 2005
  • Medicine, Chemistry
  • Drug metabolism and pharmacokinetics
  • BACKGROUND/AIM Creatinine is excreted into urine via tubular secretion in addition to glomerular filtration. In the present study, characteristics of the creatinine transport in renal epithelial cells were investigated. METHODS The transcellular transport and accumulation of [14C]creatinine and [14C]tetraethylammonium (TEA) were assessed using LLC-PK1 cell monolayers cultured on porous membrane filters. RESULTS [14C]Creatinine was transported directionally from the basolateral to apical… CONTINUE READING
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