Transcellular transactivation by the human immunodeficiency virus type 1 tat protein.

@article{Helland1991TranscellularTB,
  title={Transcellular transactivation by the human immunodeficiency virus type 1 tat protein.},
  author={Dag E Helland and Jacqueline Welles and Antonella Caputo and William A. Haseltine},
  journal={Journal of virology},
  year={1991},
  volume={65 8},
  pages={4547-9}
}
The human immunodeficiency virus type 1 (HIV-1) transactivator (tat) protein produced in one cell activated HIV-1 promoter-directed gene expression in a second cell, provided the cells were in direct contact with one another. This observation suggests that the tat protein produced in HIV-1-infected cells has a physiological effect on neighboring cells. 

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