Transcellular sodium transport in cultured cystic fibrosis human nasal epithelium.

  title={Transcellular sodium transport in cultured cystic fibrosis human nasal epithelium.},
  author={Niels Johannes Willumsen and Richard C. Boucher},
  journal={The American journal of physiology},
  volume={261 2 Pt 1},
Cystic fibrosis (CF) airway epithelia exhibit raised transepithelial Na+ transport rates, as determined by open-circuit isotope fluxes and estimates of the amiloride-sensitive equivalent short-circuit current (Ieq). To study the contribution of apical and basolateral membrane paths to raised Na+ transport in CF, CF nasal epithelial cultures were studied with double-barreled Na(+)-selective microelectrodes and the Ussing chamber technique. Intracellular Na+ activity (acNa) was 24.1 +/- 1.5 mM (n… CONTINUE READING
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