Transcellular migration of neutrophil granulocytes through the blood-cerebrospinal fluid barrier after infection with Streptococcus suis

@inproceedings{Wewer2011TranscellularMO,
  title={Transcellular migration of neutrophil granulocytes through the blood-cerebrospinal fluid barrier after infection with Streptococcus suis},
  author={Corinna Wewer and Annette Seibt and Hartwig Wolburg and Lilo Greune and M Alexander Schmidt and J{\"u}rgen Berger and Hans-Joachim Galla and Ulrike Quitsch and Christian Schwerk and Horst Schroten and Tobias Tenenbaum},
  booktitle={Journal of Neuroinflammation},
  year={2011}
}
A critical point during the course of bacterial meningitis is the excessive influx of polymorphnuclear neutrophils (PMNs) from the blood into the brain. Both paracellular and transcellular routes of leukocyte transmigration through the blood-brain barrier have been described in CNS diseases so far. Thus, we investigated the mechanism of PMN transmigration through the blood-CSF barrier under inflammatory conditions. In an "inverted" Transwell culture model of the blood-CSF barrier, the zoonotic… CONTINUE READING
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