Transcellular delivery of vesicular SOCS proteins from macrophages to epithelial cells blunts inflammatory signaling

@inproceedings{Bourdonnay2015TranscellularDO,
  title={Transcellular delivery of vesicular SOCS proteins from macrophages to epithelial cells blunts inflammatory signaling},
  author={Emilie Bourdonnay and Zbigniew Zasłona and Loka Raghu Kumar Penke and Jennifer M Speth and Daniel Jay Schneider and Sally A. Przybranowski and Joel A Swanson and Peter Mancuso and Christine M Freeman and Jeffrey L Curtis and Marc Peters-Golden},
  booktitle={The Journal of experimental medicine},
  year={2015}
}
JAK-STAT signaling mediates the actions of numerous cytokines and growth factors, and its endogenous brake is the family of SOCS proteins. Consistent with their intracellular roles, SOCS proteins have never been identified in the extracellular space. Here we report that alveolar macrophages can secrete SOCS1 and -3 in exosomes and microparticles, respectively, for uptake by alveolar epithelial cells and subsequent inhibition of STAT activation. Secretion is tunable and occurs both in vitro and… CONTINUE READING
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