Transcellular delivery of an insulin-transferrin conjugate in enterocyte-like Caco-2 cells.

  title={Transcellular delivery of an insulin-transferrin conjugate in enterocyte-like Caco-2 cells.},
  author={Darshan Shah and W C Shen},
  journal={Journal of pharmaceutical sciences},
  volume={85 12},
Insulin, acylated with dimethylmaleic anhydride, was conjugated to transferrin (Tf) via a disulfide linkage. The molar insulin: Tf ratio in the conjugate was 3:1. The insulin-Tf conjugate (insulin-Tf) was tested for the transport of insulin across enterocyte-like Caco-2 cell monolayers by the process of transferrin receptor (TfR)-mediated transcytosis. The uptake of insulin-Tf in Caco-2 cells was TfR-mediated but no insulin receptor-mediated. Transport studies showed that insulin-Tf transport… CONTINUE READING


Publications citing this paper.
Showing 1-10 of 27 extracted citations

Hypoglycemic effect of insulin-transferrin conjugate in streptozotocin-induced diabetic rats.

The Journal of pharmacology and experimental therapeutics • 2000
View 6 Excerpts
Highly Influenced

Ionic liquids for oral insulin delivery.

Proceedings of the National Academy of Sciences of the United States of America • 2018
View 1 Excerpt

Advances in oral macromolecular drug delivery.

Expert opinion on drug delivery • 2014
View 1 Excerpt

Similar Papers

Loading similar papers…