Transcellular delivery of an insulin-transferrin conjugate in enterocyte-like Caco-2 cells.

@article{Shah1996TranscellularDO,
  title={Transcellular delivery of an insulin-transferrin conjugate in enterocyte-like Caco-2 cells.},
  author={Darshan Shah and W C Shen},
  journal={Journal of pharmaceutical sciences},
  year={1996},
  volume={85 12},
  pages={1306-11}
}
Insulin, acylated with dimethylmaleic anhydride, was conjugated to transferrin (Tf) via a disulfide linkage. The molar insulin: Tf ratio in the conjugate was 3:1. The insulin-Tf conjugate (insulin-Tf) was tested for the transport of insulin across enterocyte-like Caco-2 cell monolayers by the process of transferrin receptor (TfR)-mediated transcytosis. The uptake of insulin-Tf in Caco-2 cells was TfR-mediated but no insulin receptor-mediated. Transport studies showed that insulin-Tf transport… CONTINUE READING

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