Transcellular Calcium Transport in Mammary Epithelial Cells

  title={Transcellular Calcium Transport in Mammary Epithelial Cells},
  author={Joshua N Vanhouten and John J. Wysolmerski},
  journal={Journal of Mammary Gland Biology and Neoplasia},
The time-honored paradigm for mammary gland transepithelial calcium transport into milk is centered on the view that most, if not all, calcium enters milk through the secretory pathway, and no ionic calcium directly crosses the apical plasma membrane. Data from several recent studies all strongly suggest that most calcium, in fact, is extruded across the apical plasma membrane directly by the plasma membrane calcium-ATPase isoform 2 (PMCA2). In this review we break down transcellular calcium… CONTINUE READING