Transcallosal inhibition in amyotrophic lateral sclerosis.

  title={Transcallosal inhibition in amyotrophic lateral sclerosis.},
  author={Matthias Wittstock and Alexander Wolters and Reiner Benecke},
  journal={Clinical neurophysiology : official journal of the International Federation of Clinical Neurophysiology},
  volume={118 2},
OBJECTIVE Assessment of upper motor neuron (UMN) involvement is essential for the diagnosis of amyotrophic lateral sclerosis (ALS). In a number of ALS cases, mirror movements (MM) suggest an involvement of transcallosal fibre tracts in conjunction with UMN involvement. The present study analysed whether deficient transcallosal inhibition (TI) tested by TMS enables detection of cortical affection in ALS, even at early stages of the disease. METHODS In three patients with definite ALS and 12… CONTINUE READING