Transbronchial biopsy in lymphangiomyomatosis of the lung. HMB45 for diagnosis.

  title={Transbronchial biopsy in lymphangiomyomatosis of the lung. HMB45 for diagnosis.},
  author={Franco Bonetti and Pier Luigi Chiodera and Maurizio Pea and Guido Martignoni and Federica Bosi and Giuseppe Zamboni and Gian Mario Mariuzzi},
  journal={The American journal of surgical pathology},
  volume={17 11},
We have investigated the presence of smooth muscle cells with immunoreactivity for melanoma-related marker HMB45 in pulmonary lymphangiomyomatosis (PLAM). Of 75 lung specimens, including a variety of lesions (obtained with both transbronchial and open lung biopsies), only PLAM (six specimens from three patients) showed the presence of HMB45-positive cells. In addition, 20 specimens of normal lung were unreactive with this monoclonal antibody. It is concluded that the smooth muscle cells of PLAM… CONTINUE READING
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