Transaxial tomographic imaging of canine myocardium with 11C-palmitic acid.

Abstract

Radiopharmaceuticals incorporated directly into the metabolic pathways in myocardium provide a useful means for evaluating such processes. Palmitic acid, a major physiologic substrate of myocardium, has a well-understood role in myocardial metabolism. Accordingly, 11C-palmitic acid was the substrate chosen for use in conjunction with positron emission transaxial tomography to obtain images of canine myocardium. This procedure provides high-contrast images of tranverse sections of the myocardium, with good target-to-nontarget ratios (in the image), over a period of 5 to 85 minutes. Clearance half-times for blood and myocardial tissue were found to be 4.8 and 330 min, respectively. In normal myocardium, images obtained with 11C-palmitic acid were those obtained with 13NH3 and 11CO-hemoglobin. In vivo images of hearts with myocardial infarcts showed a clear delineration of infarcts and normal tissue.

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@article{Hoffman1977TransaxialTI, title={Transaxial tomographic imaging of canine myocardium with 11C-palmitic acid.}, author={Edward J. Hoffman and M. E. Phelps and Eric S. Weiss and Michael J. Welch and R. Edward Coleman and B. E. Sobel and Michel M. Ter-Pogossian}, journal={Journal of nuclear medicine : official publication, Society of Nuclear Medicine}, year={1977}, volume={18 1}, pages={57-61} }