Transactivation of vimentin by beta-catenin in human breast cancer cells.

  title={Transactivation of vimentin by beta-catenin in human breast cancer cells.},
  author={Christine Gilles and Myriam Polette and M{\'e}lanie Mestdagt and B{\'e}atrice Nawrocki-Raby and Philippe Ruggeri and Philippe Birembaut and J. -M. Foidart},
  journal={Cancer research},
  volume={63 10},
The cytoplasmic and nuclear redistribution of beta-catenin and the de novo expression of vimentin are frequently involved in the epithelial-to-mesenchymal transition associated with increased invasive/migratory properties of epithelial cells. Because beta-catenin can act as a coactivator of transcription through its binding to the T-cell factor (TCF)/lymphoid enhancer factor 1 transcription factor family, we have explored the possibility that beta-catenin/TCF could directly transactivate… CONTINUE READING


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