Transactivation of the rat CYP2C13 gene promoter involves HNF-1, HNF-3, and members of the orphan receptor subfamily.

@article{Legraverend1994TransactivationOT,
  title={Transactivation of the rat CYP2C13 gene promoter involves HNF-1, HNF-3, and members of the orphan receptor subfamily.},
  author={C Legraverend and Hiroshi Eguchi and Anders Str{\"o}m and Olivier Lahuna and Agneta Mode and P E Tollet and Stu Westin and J A Gustafsson},
  journal={Biochemistry},
  year={1994},
  volume={33 33},
  pages={9889-97}
}
The rat CYP2C13 gene (2C13) encodes one of the constitutive male forms of cytochrome P-450 that are involved in steroid metabolism. In addition to being developmentally regulated, the expression of 2C13 is restricted to the liver and suppressed by the female pattern of growth hormone (GH) secretion at the transcriptional initiation level. In this study, we show that the liver-specific expression, but not the regulation by GH, can be reconstituted with 117 bp to 2 kb of 2C13 5' flank… CONTINUE READING
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