Transactivation of the epidermal growth factor receptor by heat shock protein 90 via Toll-like receptor 4 contributes to the migration of glioblastoma cells.

@article{Thuringer2011TransactivationOT,
  title={Transactivation of the epidermal growth factor receptor by heat shock protein 90 via Toll-like receptor 4 contributes to the migration of glioblastoma cells.},
  author={Dominique Thuringer and Arlette Hammann and Na{\"i}ma Benikhlef and Eric Fourmaux and Andre Bouchot and Guillaume Wettstein and Eric Solary and Carmen Gloria Garrido},
  journal={The Journal of biological chemistry},
  year={2011},
  volume={286 5},
  pages={
          3418-28
        }
}
Extracellular heat shock protein HSP90α was reported to participate in tumor cell growth, invasion, and metastasis formation through poorly understood signaling pathways. Herein, we show that extracellular HSP90α favors cell migration of glioblastoma U87 cells. More specifically, externally applied HSP90α rapidly induced endocytosis of EGFR. This response was accompanied by a transient increase in cytosolic Ca(2+) appearing after 1-3 min of treatment. In the presence of EGF, U87 cells showed… CONTINUE READING
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