Transactivation of the IGF-1R by aldosterone.

  title={Transactivation of the IGF-1R by aldosterone.},
  author={Jennifer L. Holzman and Lian Liu and Billie Jeanne Duke and Alexandra E. Kemendy and Douglas C. Eaton},
  journal={American journal of physiology. Renal physiology},
  volume={292 4},
Activation of epithelial sodium channels (ENaC) by aldosterone, insulin, or insulin-like growth factor-1 (IGF-1) in renal epithelial cells (including the Xenopus laevis renal cell line A6) appears to share some common signaling elements subsequent to the initial insulin or IGF-1 receptor activation. Previously, the convergence point for insulin or IGF-1 and aldosterone signaling was assumed to be downstream of the receptor at the level of phosphatidylinositol 3-kinase (PI3-K); however, this… CONTINUE READING


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