Transactivation of epidermal growth factor receptor through platelet-activating factor/receptor in ovarian cancer cells

@inproceedings{Yu2014TransactivationOE,
  title={Transactivation of epidermal growth factor receptor through platelet-activating factor/receptor in ovarian cancer cells},
  author={Yi Yu and Mingxing Zhang and Xiaoyan Zhang and Qingqing Cai and Zhiling Zhu and Wei Jiang and Congjian Xu},
  booktitle={Journal of experimental & clinical cancer research : CR},
  year={2014}
}
BACKGROUND We previously identified platelet-activating factor receptor (PAFR) as being overexpressed in ovarian cancer and found that its ligand PAF evoked EGFR phosphorylation using the phospho-antibody microarray. Epidermal growth factor receptor (EGFR) are also overexpressed in ovarian cancer and contribute to the growth of ovarian cancer cells. Here, we investigated the mechanisms of crosstalk between PAFR and EGFR signaling in ovarian cancer cells to further determine whether the… CONTINUE READING

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