Transactivation of a ribosomal gene by simian virus 40 large-T antigen requires at least three activities of the protein.

@article{Cavender1999TransactivationOA,
  title={Transactivation of a ribosomal gene by simian virus 40 large-T antigen requires at least three activities of the protein.},
  author={Jane F. Cavender and Christine Mummert and M. Judith Tevethia},
  journal={Journal of virology},
  year={1999},
  volume={73 1},
  pages={
          214-24
        }
}
Simian virus 40 large-T antigen transactivates the ribosomal genes which are transcribed by RNA polymerase (pol I), as well as genes that are dependent on either pol II or pol III. This report identifies regions and activities of T antigen that are required to transactivate a pol I-dependent rat ribosomal gene promoter. By using the rat ribosomal gene (rDNA) promoter linked to a chloramphenicol acetyltransferase gene, we show that at least three separable T-antigen regions are necessary to… CONTINUE READING

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References

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SHOWING 1-10 OF 69 REFERENCES

Regulation of human ribosomal RNA transcription.

VIEW 5 EXCERPTS
HIGHLY INFLUENTIAL

Reactivation of silent rRNA genes by simian virus 40 in human-mouse hybrid cells.

VIEW 4 EXCERPTS
HIGHLY INFLUENTIAL