Transactivation of PDGFRβ by dopamine D4 receptor does not require PDGFRβ dimerization

@inproceedings{Chi2010TransactivationOP,
  title={Transactivation of PDGFRβ by dopamine D4 receptor does not require PDGFRβ dimerization},
  author={Sum Shing Chi and Sandra M Vetiska and Robin S Gill and Marilyn S. Hsiung and Fang Liu and Hubert H M Van Tol},
  booktitle={Molecular Brain},
  year={2010}
}
Growth factor-induced receptor dimerization and cross-phosphorylation are hallmarks of signal transduction via receptor tyrosine kinases (RTKs). G protein-coupled receptors (GPCRs) can activate RTKs through a process known as transactivation. The prototypical model of RTK transactivation involves ligand-mediated RTK dimerization and cross-phosphorylation. Here, we show that the platelet-derived growth factor receptor β (PDGFRβ) transactivation by the dopamine receptor D4 (DRD4) is not dependent… CONTINUE READING
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