Transactivation of MCP-1/CCL2 by beta-catenin/TCF-4 in human breast cancer cells.

  title={Transactivation of MCP-1/CCL2 by beta-catenin/TCF-4 in human breast cancer cells.},
  author={M{\'e}lanie Mestdagt and Myriam Polette and Giovanna Buttic{\`e} and Agn{\'e}s No{\"e}l and Atsuhisa Ueda and J. -M. Foidart and Christine Gilles},
  journal={International journal of cancer},
  volume={118 1},
The loss of E-cadherin expression and the translocation of beta-catenin to the nucleus are frequently associated with the metastatic conversion of epithelial cells. In the nucleus, beta-catenin binds to the TCF/LEF-1 (T-cell factor/ lymphoid enhancer factor) transcription factor family resulting in the activation of several genes, some of them having important implications in tumour progression. In our study, we investigated the potential regulation of monocyte chemotactic protein-1 (MCP-1/CCL2… CONTINUE READING
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