Transactivation of MCP-1/CCL2 by beta-catenin/TCF-4 in human breast cancer cells.

@article{Mestdagt2006TransactivationOM,
  title={Transactivation of MCP-1/CCL2 by beta-catenin/TCF-4 in human breast cancer cells.},
  author={M{\'e}lanie Mestdagt and Myriam Polette and Giovanna Buttic{\`e} and Agn{\'e}s No{\"e}l and Atsuhisa Ueda and J. -M. Foidart and Christine Gilles},
  journal={International journal of cancer},
  year={2006},
  volume={118 1},
  pages={35-42}
}
The loss of E-cadherin expression and the translocation of beta-catenin to the nucleus are frequently associated with the metastatic conversion of epithelial cells. In the nucleus, beta-catenin binds to the TCF/LEF-1 (T-cell factor/ lymphoid enhancer factor) transcription factor family resulting in the activation of several genes, some of them having important implications in tumour progression. In our study, we investigated the potential regulation of monocyte chemotactic protein-1 (MCP-1/CCL2… CONTINUE READING
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macrophage infiltration and tumor vascularity in human gastric carcinomas

  • E Nakashima, N Mukaida, +6 authors K Matsushima
  • Int J Oncol
  • 2003

pancreatic cancer progression: regulation of expression and potential mechanisms of antimalignant activity

  • T Ueno, M Toi, +6 authors K Matsushima
  • Cancer Res
  • 2003

macrophage infiltration and tumor vascularity in human esophageal squamous cell carcinomas

  • J Behrens
  • Int J Cancer
  • 2002

expressed in cancer cells of epithelial origin

  • L Levy, C Neuveut, +8 authors MA Buendia
  • Biochem J
  • 2001

MCP-1: direct role of MCP-1 in angiogenesis and tumor progression

  • A Lebrecht, C Grimm, +4 authors H Koelbl
  • Int J Cancer
  • 2000

the human monocyte chemoattractant protein-1 gene

  • V Korinek, N Barker, +5 authors H Clevers
  • J Immunol
  • 1994

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