Transactivation of Fra-1 and consequent activation of AP-1 occur extracellular signal-regulated kinase dependently.

@article{Young2002TransactivationOF,
  title={Transactivation of Fra-1 and consequent activation of AP-1 occur extracellular signal-regulated kinase dependently.},
  author={Matthew R. Young and Rajalakshmi Nair and Natalie R Bucheimer and Preety Tulsian and Nicole Brown and Cristi Chapp and Tin-Chen Hsu and Nancy H. Colburn},
  journal={Molecular and cellular biology},
  year={2002},
  volume={22 2},
  pages={587-98}
}
Mitogen-activated protein (MAP) kinase, extracellular-signal-regulated kinases (ERKs) play an important role in activating AP-1-dependent transcription. Studies using the JB6 mouse epidermal model and a transgenic mouse model have established a requirement for AP-1-dependent transcription in tumor promotion. Tumor promoters such as 12-O-tetradecanoylphorbol-13-acetate (TPA) and epidermal growth factor induce activator protein 1 (AP-1) activity and neoplastic transformation in JB6 transformation… CONTINUE READING