Transactivation joins multiple tracks to the ERK/MAPK cascade

@article{Wetzker2003TransactivationJM,
  title={Transactivation joins multiple tracks to the ERK/MAPK cascade},
  author={Reinhard Wetzker and Frank-D. Boehmer},
  journal={Nature Reviews Molecular Cell Biology},
  year={2003},
  volume={4},
  pages={651-657}
}
Many agonists of G-protein-coupled receptors (GPCRs) can stimulate receptor tyrosine kinases and the extracellular signal-regulated kinase (ERK)/mitogen-activated protein kinase (MAPK) pathway. A 'transactivation' mechanism, which links these events in one signalling chain, inspired many researchers, but inevitably raised new questions. A 'multi-track' model for GPCR signalling to the ERK/MAPK pathway might resolve some of the puzzles in the transactivation field. 
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