Transactivation functions of the tumor-specific HMGA2/LPP fusion protein are augmented by wild-type HMGA2.

@article{Crombez2005TransactivationFO,
  title={Transactivation functions of the tumor-specific HMGA2/LPP fusion protein are augmented by wild-type HMGA2.},
  author={Koen R M O Crombez and Els M R Vanoirbeek and Wim J. M. Van de Ven and M. R. Petit},
  journal={Molecular cancer research : MCR},
  year={2005},
  volume={3 2},
  pages={63-70}
}
The gene encoding the architectural transcription factor HMGA2 is frequently rearranged in several benign tumors of mesenchymal origin. The lipoma preferred partner (LPP) gene is the most frequent translocation partner of HMGA2 in a subgroup of lipomas, which are benign tumors of adipose tissue. In these lipomas, HMGA2/LPP fusion transcripts are expressed, which encode for the three AT-hooks of HMGA2 followed by the two most carboxyl-terminal LIM domains (protein-protein interaction domains) of… CONTINUE READING

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LPP, a LIM protein highly expressed in smooth muscle.

American journal of physiology. Cell physiology • 2003
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