Transactivation-deficient Delta TA-p73 inhibits p53 by direct competition for DNA binding: implications for tumorigenesis.

@article{Stiewe2002TransactivationdeficientDT,
  title={Transactivation-deficient Delta TA-p73 inhibits p53 by direct competition for DNA binding: implications for tumorigenesis.},
  author={Thorsten Stiewe and Carmen C Theseling and Brigitte M. P{\"u}tzer},
  journal={The Journal of biological chemistry},
  year={2002},
  volume={277 16},
  pages={14177-85}
}
The p53 family member p73 displays significant structural and functional homology to p53. However, instead of mutational inactivation, overexpression of wild-type p73 has been reported in various tumor types compared with normal tissues, arguing against a classical tumor suppressor function. Recently, N-terminally truncated, transactivation-deficient p73 isoforms (DeltaTA-p73) have been identified as a second class of p73 proteins. Because overexpression of p73 in tumors includes DeltaTA-p73… CONTINUE READING

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