Trans-translation exposed: understanding the structures and functions of tmRNA-SmpB

@inproceedings{Giudice2014TranstranslationEU,
  title={Trans-translation exposed: understanding the structures and functions of tmRNA-SmpB},
  author={Emmanuel Giudice and K{\'e}vin Mac{\'e} and Reynald Gillet},
  booktitle={Front. Microbiol.},
  year={2014}
}
Ribosome stalling is a serious issue for cell survival. In bacteria, the primary rescue system is trans-translation, performed by tmRNA and its protein partner small protein B (SmpB). Since its discovery almost 20 years ago, biochemical, genetic, and structural studies have paved the way to a better understanding of how this sophisticated process takes place at the cellular and molecular levels. Here we describe the molecular details of trans-translation, with special mention of recent cryo… CONTINUE READING
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Trans-translation exposed: understanding the structures and functions of tmRNA-SmpB

E Citation Giudice, K Macé, R Gillet
  • Front. Microbiol
  • 2014