Trans-synaptic zinc mobilization improves social interaction in two mouse models of autism through NMDAR activation

@inproceedings{Lee2015TranssynapticZM,
  title={Trans-synaptic zinc mobilization improves social interaction in two mouse models of autism through NMDAR activation},
  author={E Lee and Hyejin Lee and T H Huang and Changuk Chung and Wangyong Shin and Kyungdeok Kim and Jae-Young Koh and Yi-Ping Hsueh and Eunjoon Kim},
  booktitle={Nature communications},
  year={2015}
}
Genetic aspects of autism spectrum disorders (ASDs) have recently been extensively explored, but environmental influences that affect ASDs have received considerably less attention. Zinc (Zn) is a nutritional factor implicated in ASDs, but evidence for a strong association and linking mechanism is largely lacking. Here we report that trans-synaptic Zn mobilization rapidly rescues social interaction in two independent mouse models of ASD. In mice lacking Shank2, an excitatory postsynaptic… CONTINUE READING