Trans-splicing and polyadenylation of let-7 microRNA primary transcripts.

@article{Bracht2004TranssplicingAP,
  title={Trans-splicing and polyadenylation of let-7 microRNA primary transcripts.},
  author={John Bracht and Shaun E. Hunter and Rachel A. Eachus and Phillip Weeks and Amy E Pasquinelli},
  journal={RNA},
  year={2004},
  volume={10 10},
  pages={1586-94}
}
Members of the microRNA (miRNA) class of 22-nucleotide RNAs regulate the expression of target genes that contain sequences of antisense complementarity. Maturation of miRNAs involves cleavage of longer primary transcripts, but little is yet understood about how miRNA genes are transcribed and enter the processing pathway. We find that relatively long, polyadenylated transcripts encoded by the Caenorhabditis elegans let-7 gene undergo trans-splicing to the spliced leader 1 (SL1) RNA. Deletions… CONTINUE READING

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