Trans-spliced leader addition to mRNAs in a cnidarian.

  title={Trans-spliced leader addition to mRNAs in a cnidarian.},
  author={Nicholas A. Stover and Robert E. Steele},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  volume={98 10},
A search of databases with the sequence from the 5' untranslated region of a Hydra cDNA clone encoding a receptor protein-tyrosine kinase revealed that a number of Hydra cDNAs contain one of two different sequences at their 5' ends. This finding suggested the possibility that mRNAs in Hydra receive leader sequences by trans-splicing. This hypothesis was confirmed by the finding that the leader sequences are transcribed as parts of small RNAs encoded by genes located in the 5S rRNA clusters of… CONTINUE READING


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