Trans-resveratrol-mediated inhibition of beta-oestradiol conjugation in MCF-7 cells stably expressing human sulfotransferases SULT1A1 or SULT1E1, and human liver microsomes.

Abstract

High concentrations of endogenous oestradiol (E2) correlate with the proliferation of cancer cells. Resveratrol (a dietary chemopreventive agent) at high concentrations has an anti-oestrogenic effect. E2 and resveratrol are conjugated via common uridine diphosphoglucuronosyltransferase (UGT) and sulfotransferases (SULT) enzymes. Experiments were conducted… (More)
DOI: 10.1080/00498250802604082

Topics

Cite this paper

@article{Ung2009TransresveratrolmediatedIO, title={Trans-resveratrol-mediated inhibition of beta-oestradiol conjugation in MCF-7 cells stably expressing human sulfotransferases SULT1A1 or SULT1E1, and human liver microsomes.}, author={Daniel C. X. Ung and S. Nagar}, journal={Xenobiotica; the fate of foreign compounds in biological systems}, year={2009}, volume={39 1}, pages={72-9} }