Trans-repressive effect of NUP98-PMX1 on PMX1-regulated c-FOS gene through recruitment of histone deacetylase 1 by FG repeats.

@article{Bai2006TransrepressiveEO,
  title={Trans-repressive effect of NUP98-PMX1 on PMX1-regulated c-FOS gene through recruitment of histone deacetylase 1 by FG repeats.},
  author={Xue-tao Bai and Bai-wei Gu and Tong Yin and Chao Niu and Xiao-dong Xi and Ji Zhang and Zhu Chen and Sai-juan Chen},
  journal={Cancer research},
  year={2006},
  volume={66 9},
  pages={4584-90}
}
The formation of fusion genes between NUP98 and members of the HOX family represents a critical factor for the genesis of acute leukemia or acute transformation of chronic myeloid leukemia (CML). To gain insights into the molecular mechanisms underlying the leukemogenesis of NUP98-HOX fusion products, we cloned NUP98-PMX1 from a CML-blast crisis patient with t(1;11) as a secondary chromosomal translocation, and functionally studied the fusion products in detail through various molecular and… CONTINUE READING

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