Trans-inhibition of glutamate transport prevents excitatory amino acid-induced glycolysis in astrocytes.

@article{Debernardi1999TransinhibitionOG,
  title={Trans-inhibition of glutamate transport prevents excitatory amino acid-induced glycolysis in astrocytes.},
  author={Ruth Debernardi and Pierre J. Magistretti and Luc Pellerin},
  journal={Brain research},
  year={1999},
  volume={850 1-2},
  pages={39-46}
}
Previous studies have demonstrated that activation of glutamate transporters promotes glycolysis in astrocytes. Current evidence indicates that compounds such as threo-beta-hydroxyaspartate (THA) are both competitive inhibitors and substrates for glutamate transporters. In this study, we have analyzed the effect of THA on excitatory amino acid (EAA) transport and on EAA-induced glycolysis in mouse primary astrocyte cultures. In agreement with previous studies in rat astrocytes, THA… CONTINUE READING

Citations

Publications citing this paper.
Showing 1-10 of 11 extracted citations

Similar Papers

Loading similar papers…