Trans-inactivation of receptor tyrosine kinases by novel angiotensin II AT2 receptor-interacting protein, ATIP.

@article{Nouet2004TransinactivationOR,
  title={Trans-inactivation of receptor tyrosine kinases by novel angiotensin II AT2 receptor-interacting protein, ATIP.},
  author={Sandrine Nouet and Nathalie Amzallag and Jian-Mei Li and Simon N.S. Louis and Isabell Seitz and T A Cui and Anne-Marie Alleaume and M{\'e}lanie Di Benedetto and Christine Boden and Maryline Masson and Arthur Donny Strosberg and Masatsugu Horiuchi and P Olivier Couraud and Clara Nahmias},
  journal={The Journal of biological chemistry},
  year={2004},
  volume={279 28},
  pages={28989-97}
}
Negative regulation of mitogenic pathways is a fundamental process that remains poorly characterized. The angiotensin II AT2 receptor is a rare example of a 7-transmembrane domain receptor that negatively cross-talks with receptor tyrosine kinases to inhibit cell growth. In the present study, we report the molecular cloning of a novel protein, ATIP1 (AT2-interacting protein), which interacts with the C-terminal tail of the AT2 receptor, but not with those of other receptors such as angiotensin… CONTINUE READING
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