Trans geometric isomers of EPA decrease LXRα-induced cellular triacylglycerol via suppression of SREBP-1c and PGC-1β

@inproceedings{Zaima2006TransGI,
  title={Trans geometric isomers of EPA decrease LXRα-induced cellular triacylglycerol via suppression of SREBP-1c and PGC-1β},
  author={Nobuhiro Zaima and Tatsuya Sugawara and Dai Goto and Takashi Hirata},
  year={2006}
}
Dietary mono- or di-trans fatty acids with chain lengths of 18-22 increase the risk of cardiovascular diseases because they increase LDL cholesterol and decrease HDL cholesterol in the plasma. However, the effects of trans isomers of PUFAs on lipid metabolism remain unknown. Dietary PUFAs, especially eicosapentaenoic acid (EPA) in marine oils, improve serum lipid profiles by suppressing liver X receptor a (LXRa) activity in the liver. In this study, we compared the effects of trans geometric… CONTINUE READING

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