Trans-genera reconstitution and complementation of an adhesion complex in Toxoplasma gondii.

@article{Huynh2004TransgeneraRA,
  title={Trans-genera reconstitution and complementation of an adhesion complex in Toxoplasma gondii.},
  author={M S Huynh and Corinna Opitz and Lai-Yu Kwok and F. M. Tomley and Vern B Carruthers and Dominique Soldati},
  journal={Cellular microbiology},
  year={2004},
  volume={6 8},
  pages={771-82}
}
Eimeria tenella and Toxoplasma gondii are obligate intracellular parasites belonging to the phylum Apicomplexa. In T. gondii, the microneme protein TgMIC2 contains two well-defined adhesive motifs and is thought to be a key participant in the attachment and invasion of host cells. However, several attempts by different laboratories to generate a knockout (KO) of TgMIC2 have failed, implying that TgMIC2 is an essential gene. As Eimeria and Toxoplasma utilize the same mechanisms of invasion and… CONTINUE READING

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