Trans fatty intakes during pregnancy, infancy and early childhood.

@article{Innis2006TransFI,
  title={Trans fatty intakes during pregnancy, infancy and early childhood.},
  author={Sheila M. Innis},
  journal={Atherosclerosis. Supplements},
  year={2006},
  volume={7 2},
  pages={
          17-20
        }
}
  • S. Innis
  • Published 2006
  • Biology, Medicine
  • Atherosclerosis. Supplements
All of the essential n-6 and n-3 fatty acids accumulated by the fetus must be derived by transfer from the maternal circulation, and ultimately must originate from the maternal diet. After birth, the breast-fed infant receives essential fatty acids via mother's milk, or human milk substitutes and later complementary foods. Trans fatty acids (TFA) may have adverse effects on growth and development through interfering with essential fatty acid metabolism, direct effects on membrane structures or… Expand
Human milk: maternal dietary lipids and infant development
  • S. Innis
  • Medicine, Biology
  • Proceedings of the Nutrition Society
  • 2007
TLDR
The present paper reviews current knowledge on maternal diet and human milk fatty acids, the implications of maternal diet as the only source of essential fatty acids for infant development both before and after birth, and recent studies addressing the maternal intakes and milk DHA levels associated with risk of low infant neural system maturation. Expand
[The importance of essential fatty acids and the effect of trans fatty acids in human milk on fetal and neonatal development].
TLDR
It is thus important to raise population awareness on the importance of adequate PUFA consumption and reduced TFA intake during prenatal and postnatal development. Expand
Maternal Consumption of trans-Fatty Acids During the First Half of Gestation are Metabolically Available to Suckled Newborn Rats
TLDR
Dietary t-FA, eaten during early pregnancy, accumulated in maternal adipose tissue and were released during late pregnancy to be taken up by the mammary gland becoming available to the newborns during suckling. Expand
Neonatal and fetal exposure to trans-fatty acids retards early growth and adiposity while adversely affecting glucose in mice.
TLDR
It is concluded that very early catch-up growth resulted in impaired peripheral insulin sensitivity in this model of diet-related fetal and neonatal programming and trans-fatty acid surprisingly retarded growth and adiposity while still adversely affecting glucose metabolism. Expand
Maternal trans fatty acid intake and fetal growth.
TLDR
A higher maternal intake of trans fatty acids, especially 16:1t and 18:2tc, during the second trimester of pregnancy was associated with greater fetal growth. Expand
Fatty acid distribution of cord and maternal blood in human pregnancy: special focus on individual trans fatty acids and conjugated linoleic acids
TLDR
Fetal blood fatty acid composition essentially depends on and is altered by the maternal fatty acid supply, and it can be concluded that t 11 differs from t 9 regarding its metabolism and their impact on fetal LC-PUFA. Expand
Type of fatty acids in maternal diets during pregnancy and/or lactation and metabolic consequences of the offspring.
TLDR
The maternal nutritional condition and fatty acid intake during pregnancy and/or lactation are critical factors that are strongly associated with normal fetal and postnatal development, which influence the modifications in fetal programming and in the individual risk for developing metabolic diseases throughout life. Expand
Trans Fatty Acids in Human Milk are an Indicator of Different Maternal Dietary Sources Containing Trans Fatty Acids
TLDR
It is concluded that both ratios are indicators of different intake of TFA from ruminant and dairy origin relative to other (including industrial) sources. Expand
n-3 polyunsaturated fatty acids in milk is associate to weight gain and growth in premature infants
TLDR
Considering the advantages of n-3 LC-PUFA consumption on infant growth and visual function and its association with reduced incidence of premature birth, dietitians should advise pregnant women to increase their intake of foods high in n- 3 LC- PUFA. Expand
Influence of duration of gestation on fatty acid profiles of human milk
TLDR
This thorough knowledge of lipid profile of human milk could be useful to design a more humanised infant formula in order to ensure the required FA and cholesterol levels of infants are satisfied during early life, particularly in supporting the growth and development of premature babies. Expand
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References

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trans Fatty acids in human milk are inversely associated with concentrations of essential all-cis n-6 and n-3 fatty acids and determine trans, but not n-6 and n-3, fatty acids in plasma lipids of breast-fed infants.
  • S. Innis, D. King
  • Chemistry, Medicine
  • The American journal of clinical nutrition
  • 1999
TLDR
There were comparable concentrations of trans fatty acids in the maternal diet, breast milk, and plasma triacylglycerols of breast-fed infants and the major dietary sources were bakery products and breads, snacks, fast foods, and margarines and shortenings. Expand
Isomeric fatty acids: Evaluating status and implications for maternal and child health
TLDR
The hypothesis that dietary trans-fatty acids could inhibit biosynthesis of long-chain polyunsaturated fatty acids with 20 and 22 carbon atoms and thus affect infant development is supported by studies demonstrating an inverse correlation of plasma trans- fatty acids with n−3 and n−6 long- chain polyuns saturated fatty acids in infants. Expand
Similar effects on infants of n-3 and n-6 fatty acids supplementation to pregnant and lactating women.
OBJECTIVE There have been indications that high intake of n-3 long-chain polyunsaturated fatty acids (PUFAs) during pregnancy may increase birth weight and gestational length. In addition, n-3Expand
Infant plasma trans, n-6, and n-3 fatty acids and conjugated linoleic acids are related to maternal plasma fatty acids, length of gestation, and birth weight and length.
TLDR
The results suggest possible important effects of TFAs and of AA on fetal growth and length of gestation and inverse correlations occurred between infant plasma TFA and DHA concentrations in triacylglycerols and cholesteryl esters. Expand
Bakery foods are the major dietary source of trans-fatty acids among pregnant women with diets providing 30 percent energy from fat.
TLDR
Dietitians should educate pregnant clients about hidden sources of trans-fatty acids and emphasize the importance of dietary fat composition in women following diets providing about 30% energy from fat. Expand
Differential effects of dietary saturated and trans-fatty acids on expression of genes associated with insulin sensitivity in rat adipose tissue.
TLDR
The effects of SFAs on the aforementioned genes except PPARgamma could be extrapolated towards decreased insulin sensitivity, while only the alteration in the mRNA levels of PPargamma and resistin could be associated with insulin resistance in TFA-fed rats. Expand
Intake of trans fatty acids in western Europe: the TRANSFAIR study
TLDR
Trans fatty acids occur in fat from ruminant-animal meat, dairy fat, and in industrially hardened vegetable and marine oils, used as a substitute for saturated fats, and it is uncertain whether or not TFA are more harmful than saturated fatty acids. Expand
Perinatal biochemistry and physiology of long-chain polyunsaturated fatty acids.
  • S. Innis
  • Biology, Medicine
  • The Journal of pediatrics
  • 2003
TLDR
Although there is no evidence that the ability to form ARA from linoleic acid is limiting, supplementation with DHA reduces tissue ARA, possibly creating a conditional need for ARA in infants with a dietary intake of DHA. Expand
Essential fatty acid transfer and fetal development.
TLDR
Estimation of fetal tissue fatty acid accretion suggests that current preterm infant feeds are unlikely to meet in utero rates of 22:6n-3 accretion, and consideration needs to be given to whether fetal plasma 22: 6n- 3 and 20:4n-6 enrichment and the low 18:2n- 6 facilitates accretion of 22-6n -3 and 20-4-6 in developing tissues. Expand
Trans fatty acid isomers in Canadian human milk
TLDR
Using the totaltrans values in human milk determined in the present study, the intake of totaltrans fatty acids from various dietary sources by Canadian lactating women was estimated to be 10.6±3.7 g/person/d, and in some individuals, it could be as high as 20.3 g/d. Expand
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