Trans fatty intakes during pregnancy, infancy and early childhood.

  title={Trans fatty intakes during pregnancy, infancy and early childhood.},
  author={Sheila Margaret Innis},
  journal={Atherosclerosis. Supplements},
  volume={7 2},
  • S. Innis
  • Published 1 May 2006
  • Medicine
  • Atherosclerosis. Supplements

Human milk: maternal dietary lipids and infant development

  • S. Innis
  • Medicine
    Proceedings of the Nutrition Society
  • 2007
The present paper reviews current knowledge on maternal diet and human milk fatty acids, the implications of maternal diet as the only source of essential fatty acids for infant development both before and after birth, and recent studies addressing the maternal intakes and milk DHA levels associated with risk of low infant neural system maturation.

[The importance of essential fatty acids and the effect of trans fatty acids in human milk on fetal and neonatal development].

It is thus important to raise population awareness on the importance of adequate PUFA consumption and reduced TFA intake during prenatal and postnatal development.

Maternal Consumption of trans-Fatty Acids During the First Half of Gestation are Metabolically Available to Suckled Newborn Rats

Dietary t-FA, eaten during early pregnancy, accumulated in maternal adipose tissue and were released during late pregnancy to be taken up by the mammary gland becoming available to the newborns during suckling.

Maternal trans fatty acid intake and fetal growth.

A higher maternal intake of trans fatty acids, especially 16:1t and 18:2tc, during the second trimester of pregnancy was associated with greater fetal growth.

Fatty acid distribution of cord and maternal blood in human pregnancy: special focus on individual trans fatty acids and conjugated linoleic acids

Fetal blood fatty acid composition essentially depends on and is altered by the maternal fatty acid supply, and it can be concluded that t 11 differs from t 9 regarding its metabolism and their impact on fetal LC-PUFA.

Type of fatty acids in maternal diets during pregnancy and/or lactation and metabolic consequences of the offspring.

Trans Fatty Acids in Human Milk are an Indicator of Different Maternal Dietary Sources Containing Trans Fatty Acids

It is concluded that both ratios are indicators of different intake of TFA from ruminant and dairy origin relative to other (including industrial) sources.

n-3 polyunsaturated fatty acids in milk is associate to weight gain and growth in premature infants

Considering the advantages of n-3 LC-PUFA consumption on infant growth and visual function and its association with reduced incidence of premature birth, dietitians should advise pregnant women to increase their intake of foods high in n- 3 LC- PUFA.

Influence of duration of gestation on fatty acid profiles of human milk

This thorough knowledge of lipid profile of human milk could be useful to design a more humanised infant formula in order to ensure the required FA and cholesterol levels of infants are satisfied during early life, particularly in supporting the growth and development of premature babies.



trans Fatty acids in human milk are inversely associated with concentrations of essential all-cis n-6 and n-3 fatty acids and determine trans, but not n-6 and n-3, fatty acids in plasma lipids of breast-fed infants.

  • S. InnisD. King
  • Chemistry, Medicine
    The American journal of clinical nutrition
  • 1999
There were comparable concentrations of trans fatty acids in the maternal diet, breast milk, and plasma triacylglycerols of breast-fed infants and the major dietary sources were bakery products and breads, snacks, fast foods, and margarines and shortenings.

Isomeric fatty acids: Evaluating status and implications for maternal and child health

The hypothesis that dietary trans-fatty acids could inhibit biosynthesis of long-chain polyunsaturated fatty acids with 20 and 22 carbon atoms and thus affect infant development is supported by studies demonstrating an inverse correlation of plasma trans- fatty acids with n−3 and n−6 long- chain polyuns saturated fatty acids in infants.

Similar effects on infants of n-3 and n-6 fatty acids supplementation to pregnant and lactating women.

OBJECTIVE There have been indications that high intake of n-3 long-chain polyunsaturated fatty acids (PUFAs) during pregnancy may increase birth weight and gestational length. In addition, n-3

Infant plasma trans, n-6, and n-3 fatty acids and conjugated linoleic acids are related to maternal plasma fatty acids, length of gestation, and birth weight and length.

The results suggest possible important effects of TFAs and of AA on fetal growth and length of gestation and inverse correlations occurred between infant plasma TFA and DHA concentrations in triacylglycerols and cholesteryl esters.

Differential effects of dietary saturated and trans-fatty acids on expression of genes associated with insulin sensitivity in rat adipose tissue.

The effects of SFAs on the aforementioned genes except PPARgamma could be extrapolated towards decreased insulin sensitivity, while only the alteration in the mRNA levels of PPargamma and resistin could be associated with insulin resistance in TFA-fed rats.

Perinatal biochemistry and physiology of long-chain polyunsaturated fatty acids.

  • S. Innis
  • Medicine, Biology
    The Journal of pediatrics
  • 2003
Although there is no evidence that the ability to form ARA from linoleic acid is limiting, supplementation with DHA reduces tissue ARA, possibly creating a conditional need for ARA in infants with a dietary intake of DHA.

Essential fatty acid transfer and fetal development.

Trans fatty acid isomers in Canadian human milk

Using the totaltrans values in human milk determined in the present study, the intake of totaltrans fatty acids from various dietary sources by Canadian lactating women was estimated to be 10.6±3.7 g/person/d, and in some individuals, it could be as high as 20.3 g/d.