Trans fatty acids and cardiovascular risk: A unique cardiometabolic imprint?

@article{Mozaffarian2007TransFA,
  title={Trans fatty acids and cardiovascular risk: A unique cardiometabolic imprint?},
  author={Dariush Mozaffarian and Walter C. Willett},
  journal={Current Atherosclerosis Reports},
  year={2007},
  volume={9},
  pages={486-493}
}
Evidence from randomized controlled trials indicates that consumption of trans fatty acids (TFA) leads to harmful changes in serum lipids, systemic inflammation, endothelial function, and, in nonhuman primates, visceral adiposity and insulin resistance. Prospective observational studies demonstrate strong positive associations between TFA consumption and risk of myocardial infarction, coronary heart disease death, and sudden death. Links have also been seen between TFA intake and incidence of… Expand
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Trans fatty acids: effects on cardiometabolic health and implications for policy.
TLDR
The documented harmful effects of TFA along with the feasibility of substituting partially hydrogenated vegetable oils with healthy alternatives indicate little reason for continued presence of industrially produced TFA in food preparation and manufacturing or in home cooking fats/oils. Expand
Trans-fatty acids and nonlipid risk factors
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The multiple adverse effects and implicated pathways are consistent with the observed strong associations of TFA consumption with CHD risk, and explain why T FA consumption may adversely impact other non-CHD diseases and end points. Expand
Trans fatty acids: effects on metabolic syndrome, heart disease and diabetes
TLDR
The documented adverse effects of TFAs underscore their potential to cause harm and the importance of policy measures to minimize consumption of industrially produced TFAs. Expand
Health effects of trans-fatty acids: experimental and observational evidence
TLDR
Controlled trials and observational studies provide concordant evidence that consumption of TFA from partially hydrogenated oils adversely affects multiple cardiovascular risk factors and contributes significantly to increased risk of CHD events. Expand
Consumption of Oxidized and Partially Hydrogenated Oils Differentially Induces Trans-Fatty Acids Incorporation in Rats' Heart and Dyslipidemia
TLDR
In conclusion, process-induced TFAs cause changes including proatherogenic plasma lipid markers, heart fatty acid profiles, and coronary artery histology depending on the TFA level in the supplemented fat and therefore on the type of technological process used. Expand
A prospective study of intake of trans-fatty acids from ruminant fat, partially hydrogenated vegetable oils, and marine oils and mortality from CVD
TLDR
The present study supports that TFA intake, irrespective of source, increases CVD risk and whether TFA from PHVO decreases risk of cerebrovascular diseases warrants further investigation. Expand
Fatty Acids, Cardiovascular Diseases, and Diabetes Mellitus
TLDR
This dissertation investigated the prospective associations of five subtypes of plasma phospholipid trans fatty acid (TFA) levels with the risk of various disease endpoints, including total, CVD and non-CVD mortality, incident coronary heart disease (CHD) and DM. Expand
Trans fatty acids, cardiovascular health, and policy implications
TLDR
Both individual-level and policy-level initiatives to reduce the global consumption of industrial TFA intake should be a priority. Expand
Trans fatty acids consumption in type 1 diabetic patients: evaluation by dietary records and measurement in serum phospholipids
TLDR
The data indicate that the intake of trans fatty acids is relatively low in the population, i.e.,<1% of total calories in the diet, in line with what recommended by the World Health Organization. Expand
Impact of Nonoptimal Intakes of Saturated, Polyunsaturated, and Trans Fat on Global Burdens of Coronary Heart Disease
TLDR
Nonoptimal intakes of n‐6 PUFA, TFA, and SFA each contribute to significant estimated CHD mortality, with important heterogeneity across countries that informs nation‐specific clinical, public health, and policy priorities. Expand
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TLDR
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