Trans-dominant inhibition of RNA viral replication can slow growth of drug-resistant viruses

@article{Crowder2005TransdominantIO,
  title={Trans-dominant inhibition of RNA viral replication can slow growth of drug-resistant viruses},
  author={S. Crowder and K. Kirkegaard},
  journal={Nature Genetics},
  year={2005},
  volume={37},
  pages={701-709}
}
The high error rates of viral RNA-dependent RNA polymerases create heterogeneous viral populations whose disparate RNA genomes affect each other's survival. We systematically screened the poliovirus genome and identified four sets of dominant mutations. Mutated alleles in capsid- and polymerase-coding regions resulted in dominant negative phenotypes, probably due to the proteins' oligomeric properties. We also identified dominant mutations in an RNA element required for priming RNA synthesis… Expand
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