Trans-dentinal Stimulation of Tertiary Dentinogenesis

  title={Trans-dentinal Stimulation of Tertiary Dentinogenesis},
  author={A. J. Smith and Peter E. Murray and Alastair James Sloan and John B. Matthews and S Zhao},
  journal={Advances in Dental Research},
  pages={51 - 54}
Trans-dentinal stimulation of tertiary dentinogenesis has long been recognized, and has traditionally been ascribed to diffusion of irritant substances arising during injury and restorative treatment. Identification of bio-active components, especially growth factors including TGF-βs, sequestered within dentin matrix provides a new explanation for cellular signaling during tertiary dentinogenesis. Both isolated dentin matrix components and pure growth factors (TGF-βs) have been shown to signal… 

The Future Role of a Molecular Approach to Pulp-Dentinal Regeneration

  • D. Tziafas
  • Medicine, Materials Science
    Caries Research
  • 2004
Experimental investigations in mature teeth have shown that a network of extracellular matrix molecules and growth factors signal tertiary dentinogenesis, and promising biologically active substances should be subjected to careful evaluation in well-designed preclinical investigations as well as in long-term clinical trials.

The role of transforming growth factor beta in tertiary dentinogenesis

The role of TGF- b on tertiary dentinogenesis during the progression of a carious lesion is summarized.

Influence of root canal disinfectants on growth factor release from dentin.

Can interaction of materials with the dentin-pulp complex contribute to dentin regeneration?

Current knowledge about the potential beneficial effects derived from the interaction of dental materials with the dentin-pulp complex, as well as potential future developments in this exciting field are summarized.

Dentinogenic potential of the dental pulp: facts and hypotheses

The aim of the present article is to discuss observations and hypotheses from different experimental approaches on the biological mechanisms underlying initiation of tertiary dentin formation and

Responses of the pulp–dentin organ to dental restorative biomaterials

Important factors for long-term pulpal outcome are microleakage with possible bacterial penetration and leakage products from restorative materials and the remaining thickness of sound dentin.

Dentine extracellular matrix components liberated by calcium silicate cements and their effects on dental pulp cells

A previously unidentified growth factor in dECM, hepatocyte growth factor, was shown to induce pulp cell proliferation, migration, differentiation and mineralisation in vitro, and growth factors liberated from dentine by the soluble components of pulp capping agents may regulate reparative events leading to pulp wound healing in vivo.

The use of dentin matrix scaffold and dental follicle cells for dentin regeneration.

Biodentine(TM) induces TGF-β1 release from human pulp cells and early dental pulp mineralization.

When Biodentine™ was applied directly onto the pulp, it induced an early form of reparative dentine synthesis, probably due to a modulation of pulp cell TGF-β1 secretion.



Reactionary dentinogenesis.

Reactionary dentinogenesis is the secretion of a tertiary dentine matrix by surviving odontoblast cells in response to an appropriate stimulus. Whilst this stimulus may be exogenous in nature, it may

Odontoblast stimulation in ferrets by dentine matrix components.

Preliminary studies on pulp capping with demineralized dentin.

  • W. C. RobsonR. W. Katz
  • Materials Science, Medicine
    Proceedings of the Finnish Dental Society. Suomen Hammaslaakariseuran toimituksia
  • 1992
Preliminary work suggests that osteoinductive factors present in demineralized incisor dentin might be used to guide the formation of a dentin bridge in a rat model for vital pulp exposures.

Preliminary studies on pulp capping with demineralized dentin.

It is suggested that osteoinductive factors present in demineralized incisor dentin might be used to guide the formation of a dentin bridge in a rat model for vital pulp exposures.

Cavity remaining dentin thickness and pulpal activity.

Investigation of pulpal injury by measuring odontoblast numbers, and pulp dentin repair activity by measuring reactionary dentin area, in relation to the remaining dentin thickness (RDT) of cavity preparations in 217 human teeth found reactionary dentin deposition was observed beneath cavities with a RDT above 0.5 mm.

Reparative dentin formation in rat molars after direct pulp capping with growth factors.

Designing new treatment strategies in vital pulp therapy.

In vivo morphogenetic activity of dentine matrix proteins.

Dentine matrix proteins implanted in exposed pulps of teeth provide a good experimental model for analysing the cell-matrix interactions and events taking place during odontoblast differentiation and dentinogenesis.