Trans-complementation of polyhedrin by a stably transformed Sf9 insect cell line allows occ- baculovirus occlusion and larval per os infectivity.

@article{Lpez2010TranscomplementationOP,
  title={Trans-complementation of polyhedrin by a stably transformed Sf9 insect cell line allows occ- baculovirus occlusion and larval per os infectivity.},
  author={Mar{\'i}a Gabriela L{\'o}pez and Victoria Alfonso and Elisa Carrillo and Oscar Taboga},
  journal={Journal of biotechnology},
  year={2010},
  volume={145 2},
  pages={
          199-205
        }
}
Oral infection of insect larvae with baculovirus is an advantageous methodology for producing high levels of recombinant proteins and for achieving plague control. However, many recombinant baculoviruses express a foreign protein in lieu of the polyhedrin and hence do not form occlusion bodies (occ-), resulting in extremely reduced per os infectivity in larvae. To overcome this limitation, stably transformed insect cell lines expressing polyhedrin capable of occluding occ- recombinant… CONTINUE READING

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