Trans-complementation of HCV replication by non-structural protein 5A.

  title={Trans-complementation of HCV replication by non-structural protein 5A.},
  author={Xiao Mei Tong and Bruce A. Malcolm},
  journal={Virus research},
  volume={115 2},
Although establishment of the subgenomic replicon system has considerably facilitated genetic analysis of HCV replication, many details remain largely unknown. To initially test whether HCV replication could be affected in trans, complementation studies were conducted in which defective replicon RNAs carrying a luciferase reporter were introduced into stable cells bearing functional replicons. The NS3 protease and the NS5B viral polymerase genes on the transfected replicons were rendered null… CONTINUE READING
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