Trans-cinnamaldehyde from Cinnamomum zeylanicum bark essential oil reduces the clindamycin resistance of Clostridium difficile in vitro.

@article{Shahverdi2007TranscinnamaldehydeFC,
  title={Trans-cinnamaldehyde from Cinnamomum zeylanicum bark essential oil reduces the clindamycin resistance of Clostridium difficile in vitro.},
  author={Ahmad Reza Shahverdi and Hamid Reza Monsef-Esfahani and Fatemeh Tavasoli and Alireza Zaheri and Roohollah Mirjani},
  journal={Journal of food science},
  year={2007},
  volume={72 1},
  pages={S055-8}
}
Therapy with antimicrobial drugs, such as clindamycin, that perturb the intestinal flora but fail to inhibit growth of other microorganisms can permit the proliferation of Clostridium difficile and the elaboration of exotoxin. Therefore, there has been increasing interest in the use of inhibitors of antibiotic resistance for use in combination therapy. The essential oil of Cinnamomum zeylanicum bark enhanced the bactericidal activity of clindamycin and decreased the minimum inhibitory… CONTINUE READING

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