Trans-arachidonic acids: new mediators of nitro-oxidative stress.

@article{Balazy2008TransarachidonicAN,
  title={Trans-arachidonic acids: new mediators of nitro-oxidative stress.},
  author={M. Balazy and S. Chemtob},
  journal={Pharmacology \& therapeutics},
  year={2008},
  volume={119 3},
  pages={
          275-90
        }
}
A reaction of arachidonic acid with the nitrogen dioxide radical (*NO2) or its precursors (peroxynitrite, nitrous acid, nitrogen trioxide) generates a group of nitro lipids named nitroeicosanoids. A distinct feature of this reaction is abundant formation of four trans isomers of arachidonic acid (TAA) via reversible addition of the NO2 radical to the arachidonic acid cis double bonds. This cis-trans isomerization is biologically relevant because many pathologies that involve NO formation such… Expand
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