Trans-ancestry genome-wide association study identifies 12 genetic loci influencing blood pressure and implicates a role for DNA methylation

@article{Kato2015TransancestryGA,
  title={Trans-ancestry genome-wide association study identifies 12 genetic loci influencing blood pressure and implicates a role for DNA methylation},
  author={Norihiro Kato and Marie Loh and Fumihiko Takeuchi and Niek Verweij and Xu Wang and Wenlei Zhang and Tanika N. Kelly and Danish Saleheen and Benjamin Lehne and Irene Mateo Leach and Alexander W. Drong and James Abbott and Simone Wahl and Sian-Tsung Tan and William Robert Scott and Gianluca Campanella and Marc Chadeau-Hyam and Uzma Afzal and Tarunveer S Ahluwalia and Marc Jan Bonder and Peng Chen and Abbas Dehghan and Todd L. Edwards and T{\"o}nu Esko and Min Jin Go and Sarah E Harris and Jaana Hartiala and Silva Kasela and Anuradhani Kasturiratne and Chiea Chuen Khor and Marcus E. Kleber and Huaixing Li and Zuan Yu Mok and Masahiro Nakatochi and Nur Sabrina Sapari and Richa Saxena and Alexandre F R Stewart and Lisette Stolk and Yasuharu Tabara and Ai Ling Teh and Ying Wu and Jer-Yuarn Wu and Yi Zhang and Imke Aits and Alexessander Couto Alves and Shikta Das and Rajkumar Dorajoo and Jemma C Hopewell and Yun Kyoung Kim and Robert W. Koivula and Jian'an Luan and Leo-Pekka Lyytik{\"a}inen and Quang Ninh Nguyễn and Mark A Pereira and Iris Postmus and Olli T. Raitakari and Molly Scannell Bryan and Robert Andrew Donald Scott and Rossella Sorice and Vinicius Tragante and Michela Traglia and Jill M White and Ken Yamamoto and Yonghong Zhang and Linda S. Adair and Alauddin Ahmed and Koichi Akiyama and Rasheed Asif and Tin Aung and In{\^e}s Barroso and Andrew C. Bjonnes and Timothy R Braun and Hui Cai and Li-ching Chang and Chien-Hsiun Chen and Ching-Yu Cheng and Yap-Seng Chong and R{\'o}n{\'a}n Collins and Regina Courtney and Gail E. Davies and Graciela D{\'i}az de Delgado and Loi Doan Do and Pieter Afm Doevendans and Ronald T. Gansevoort and Yu-tang Gao and Tanja B. Grammer and Niels Grarup and Jagvir Grewal and Dongfeng Gu and Gurpreet Singh Wander and Anna-Liisa Hartikainen and Stanley L. Hazen and Jing He and Chew-Kiat Heng and James E. Hixson and Albert Hofman and Chris Hsu and Wei Huang and Lise Lotte Nystrup Husemoen and Joo-Yeon Hwang and Sahoko Ichihara and Michiya Igase and Masato Isono and Johanne Marie Justesen and Tomohiro Katsuya and Muhammad G Kibriya and Young Jin Kim and Miyako Kishimoto and Woon Puay Koh and Katsuhiro Kohara and Meena K Kumari and Kenneth Kwek and Nanette R. Lee and Jeannette Lee and Jiemin Liao and Wolfgang Lieb and David C M Liewald and Tatsuaki Matsubara and Yumi Matsushita and Thomas Meitinger and Evelin Mihailov and Lili Milani and Rebecca Mills and Nina Mononen and Martina M{\"u}ller-Nurasyid and Toru Nabika and Eitaro Nakashima and Hong Kiat Ng and Kjell Nikus and Teresa Nutile and Takayoshi Ohkubo and Ohnaka Keizo and Sarah Parish and Lavinia Paternoster and Hao Peng and Annette Peters and Son Truong Pham and M. J. Pinidiyapathirage and Mahfuzar Rahman and Hiromi Rakugi and Olov Rolandsson and Michelle Ann Rozario and Daniela Ruggiero and Cinzia Sala and Ralhan Sarju and Kazuro Shimokawa and Harold Snieder and Thomas Spars{\o} and Wilko Spiering and John M Starr and David J. Stott and Daniel O. Stram and Takao Sugiyama and Silke Szymczak and W H Wilson Tang and Lin Lin Tong and Stella Trompet and V{\"a}in{\"o} Turjanmaa and Hirotsugu Ueshima and Andr{\'e} G. Uitterlinden and Shinobu Umemura and Marja Vaarasmaki and Rob M. van Dam and Wiek H. van Gilst and Dirk J. van Veldhuisen and Jorma Viikari and Melanie Waldenberger and Yiqin Wang and Aili Wang and Rory Wilson and T. -T. Wong and Yong-Bing Xiang and Satoshi Yamaguchi and Xingwang Ye and Robin Darling Young and Terri L Young and J Yuan and Xueya Zhou and Folkert W. Asselbergs and Marina Ciullo and Robert Clarke and Panagiotis Deloukas and Andre Franke and Paul W Franks and Steve Franks and Yechiel Friedlander and Myron D. Gross and Zhirong Guo and Torben Hansen and Marjo-Riitta Jarvelin and Torben J{\o}rgensen and J. Wouter Jukema and Mika K{\"a}h{\"o}nen and Hiroshi Kajio and Mika Kivimaki and Jong-Young Lee and Terho Lehtim{\"a}ki and Allan Linneberg and Tetsuro Miki and Oluf Pedersen and Nilesh J. Samani and Thorkild I. A. S{\o}rensen and Ryoichi Takayanagi and Daniela Toniolo and Habibul Ahsan and Hooman Allayee and Yuan-Tsong Chen and John Danesh and Ian J. Deary and Oscar H Franco and Lude Franke and Bastiaan T Heijman and Joanna D. Holbrook and Aaron Isaacs and Bong-Jo Kim and Xu Lin and Jianjun Liu and Winfried M{\"a}rz and Andres Metspalu and Karen L. Mohlke and Dharambir K Sanghera and Xiao-ou Shu and J. B. van Meurs and Eranga N. Vithana and Ananda Rajitha Wickremasinghe and Cisca Wijmenga and Bruce H W Wolffenbuttel and Mitsuhiro Yokota and Wei Zheng and Dingliang Zhu and Paolo Vineis and Soterios A Kyrtopoulos and Jos C. S. Kleinjans and Mark I. McCarthy and Richie Soong and Christian Gieger and James Samson Scott and Yik-Ying Teo and Jiang Shan He and Paul Elliott and E Shyong Tai and Pim van der Harst and Jaspal Singh Kooner and John Campbell Chambers},
  journal={Nature Genetics},
  year={2015},
  volume={47},
  pages={1282-1293}
}
We carried out a trans-ancestry genome-wide association and replication study of blood pressure phenotypes among up to 320,251 individuals of East Asian, European and South Asian ancestry. We find genetic variants at 12 new loci to be associated with blood pressure (P = 3.9 × 10−11 to 5.0 × 10−21). The sentinel blood pressure SNPs are enriched for association with DNA methylation at multiple nearby CpG sites, suggesting that, at some of the loci identified, DNA methylation may lie on the… CONTINUE READING

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References

Publications referenced by this paper.
SHOWING 1-10 OF 47 REFERENCES

The effect of genotype and in utero environment on interindividual variation in neonate DNA methylomes

Teh, A.L
  • Genome Res
  • 2014

Genome-wide association analysis of blood-pressure traits in African-ancestry individuals reveals common associated genes in African and non-African populations

N Franceschini
  • Am. J. Hum. Genet
  • 2013