Trans-ancestry analysis reveals genetic and nongenetic associations with COVID-19 susceptibility and severity.

@article{Shelton2021TransancestryAR,
  title={Trans-ancestry analysis reveals genetic and nongenetic associations with COVID-19 susceptibility and severity.},
  author={J. Shelton and A. J. Shastri and C. Ye and C. H. Weldon and Teresa Filshtein-Sonmez and D. Coker and Antony Symons and J. Esparza-Gordillo and S. Aslibekyan and A. Auton},
  journal={Nature genetics},
  year={2021}
}
COVID-19 presents with a wide range of severity, from asymptomatic in some individuals to fatal in others. Based on a study of 1,051,032 23andMe research participants, we report genetic and nongenetic associations with testing positive for SARS-CoV-2, respiratory symptoms and hospitalization. Using trans-ancestry genome-wide association studies, we identified a strong association between blood type and COVID-19 diagnosis, as well as a gene-rich locus on chromosome 3p21.31 that is more strongly… Expand
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