Trans-activation of TRPV1 by D1R in mouse dorsal root ganglion neurons.

  title={Trans-activation of TRPV1 by D1R in mouse dorsal root ganglion neurons.},
  author={Dong Woo Lee and Pyung Sun Cho and Han Kyu Lee and Sang Hoon Lee and Sung Jun Jung and Seog Bae Oh},
  journal={Biochemical and biophysical research communications},
  volume={465 4},
TRPV1, a ligand-gated ion channel expressed in nociceptive sensory neurons is modulated by a variety of intracellular signaling pathways. Dopamine is a neurotransmitter that plays important roles in motor control, cognition, and pain modulation in the CNS, and acts via a variety of dopamine receptors (D1R-D5R), a class of GPCRs. Although nociceptive sensory neurons express D1-like receptors, very little is known about the effect of dopamine on TRPV1 in the peripheral nervous system. Therefore… CONTINUE READING