Trans Fat Diet Induces Abdominal Obesity and Changes in Insulin Sensitivity in Monkeys

@article{Kavanagh2007TransFD,
  title={Trans Fat Diet Induces Abdominal Obesity and Changes in Insulin Sensitivity in Monkeys},
  author={K. Kavanagh and K. L. Jones and J. Sawyer and K. Kelley and J. Carr and J. D. Wagner and L. Rudel},
  journal={Obesity},
  year={2007},
  volume={15}
}
Objective: There is conflicting evidence about the propensity of trans fatty acids (TFAs) to cause obesity and insulin resistance. The effect of moderately high intake of dietary monounsaturated TFAs on body composition and indices of glucose metabolism was evaluated to determine any pro‐diabetic effect in the absence of weight gain. 
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180 Citations
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Methods Citations
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180 Citations

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TLDR
Dietary fat has a role in both the etiology and prevention of insulin resistance and type 2 diabetes and the role of dietary fat is controversial as fatty acids act as signaling molecules in a variety of metabolic pathways. Expand
Trans fatty acids and weight gain
TLDR
There is limited but consistent evidence that increased TFA consumption may result in a small additional weight gain, and data from a primate model suggest that TFA may have a greater adipogenic effect than cis monounsaturated fatty acids. Expand
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TLDR
The associations of objectively measured plasma TFA concentrations with diabetes in a large population‐based study among US adults are examined. Expand
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TLDR
High TFA intake did not affect glucose metabolism over 16 weeks in postmenopausal overweight women, and a study population with a stronger predisposition to insulin resistance and/or a longer duration of exposure may be required for insulin sensitivity to be affected by intake of industrial TFA. Expand
Regulators of Mitochondrial Quality Control Differs in Subcutaneous Fat of Metabolically Healthy and Unhealthy Obese Monkeys
TLDR
This study aimed to document the first spontaneous animal model of MHO and MUO and differences in SQ adipose tissue and underlying differences in the ability of subcutaneous fat to respond to nutrient excess. Expand
Trans fatty acids, cardiovascular health, and policy implications
TLDR
Both individual-level and policy-level initiatives to reduce the global consumption of industrial TFA intake should be a priority. Expand
A comparison of effects of lard and hydrogenated vegetable shortening on the development of high-fat diet-induced obesity in rats
TLDR
It is concluded that lard-based high-fat diets accentuate the increase in weight gain and the development of obesity and insulin resistance more than hydrogenated vegetable-shortening diets. Expand
Dietary fats and prevention of type 2 diabetes.
TLDR
The evidence suggests that replacing saturated fats and trans fatty acids with unsaturated (polyunsaturated and/or monounsaturated) fats has beneficial effects on insulin sensitivity and is likely to reduce risk of type 2 diabetes. Expand
Effect of trans fatty acid intake on abdominal and liver fat deposition and blood lipids: a randomized trial in overweight postmenopausal women
TLDR
The adverse effect of dietary TFA on cardiovascular disease risk involves induction of dyslipidemia, and perhaps body fat, whereas weight gain-independent accumulation of ectopic fat could not be identified as a contributory factor during short-term intake. Expand
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References

SHOWING 1-10 OF 43 REFERENCES
High- versus low-fat diets in human diseases
  • T. Sanders
  • Medicine
  • Current opinion in clinical nutrition and metabolic care
  • 2003
TLDR
A modest reduction in fat intake to 30-35% energy, with the bulk of carbohydrates being derived from complex carbohydrates from unrefined sources, would appear to be the best option for the prevention of obesity and cardiovascular disease. Expand
Is insulin resistance influenced by dietary linoleic acid and trans fatty acids?
  • A. Simopoulos
  • Chemistry, Medicine
  • Free radical biology & medicine
  • 1994
TLDR
Clinical investigations are needed to evaluate if lowering or preventing insulin resistance through diet by increasing arachidonic acid, eicosapentaenoic acid, and docosahexaenoic Acid, while lowering linoleic acid and decreasing trans fatty acids from the diet, will modify or prevent the development of these diseases. Expand
Diet and risk of Type II diabetes: the role of types of fat and carbohydrate
TLDR
Dietary recommendations to prevent Type II diabetes should focus more on the quality of fat and carbohydrate in the diet than quantity alone, in addition to balancing total energy intake with expenditure to avoid overweight and obesity. Expand
Obesity-induced inflammatory changes in adipose tissue.
TLDR
This issue of the JCI reports that obese adipose tissue is characterized by macrophage infiltration and that these macrophages are an important source of inflammation in this tissue. Expand
A high-trans fatty acid diet and insulin sensitivity in young healthy women.
TLDR
In young healthy women, the TFA diet resulted in a higher total/HDL cholesterol ratio and an elevation in triglyceride and apo B concentrations but had no effect on glucose and insulin metabolism compared with the MUFA diet. Expand
Intake of a Diet High in Trans Monounsaturated Fatty Acids or Saturated Fatty Acids: Effects on postprandial insulinemia and glycemia in obese patients with NIDDM
TLDR
In the presence of unchanged glycemia, both dietary trans fatty acids and SFAs induce an increase in postprandial insulinemia in obese patients with NIDDM. Expand
Comparison of the acute response to meals enriched with cis- or trans-fatty acids on glucose and lipids in overweight individuals with differing FABP2 genotypes.
TLDR
Data show that a single meal enriched with C18:1trans-fatty acids can significantly increase insulin resistance, and that in the presence of the FABP2 Thr54 allele, may contribute to increased partitioning of glucose to triacylglycerols and insulin resistance. Expand
Effects of diets enriched in saturated (palmitic), monounsaturated (oleic), or trans (elaidic) fatty acids on insulin sensitivity and substrate oxidation in healthy adults.
TLDR
Dietary fatty acid composition significantly influenced fat oxidation but did not impact insulin sensitivity or secretion in lean individuals, and overweight individuals were more susceptible to developing insulin resistance on high-saturated fat diets. Expand
Diet composition and the risk of type 2 diabetes: epidemiological and clinical evidence.
TLDR
New emphasis on prevention by multiple lifestyle modifications, including moderate changes in the composition of the habitual diet, might limit the dramatic increase in incidence of type 2 diabetes envisaged worldwide. Expand
Chronic inflammation in fat plays a crucial role in the development of obesity-related insulin resistance.
TLDR
It is proposed that obesity-related insulin resistance is, at least in part, a chronic inflammatory disease initiated in adipose tissue, and that macrophage-related inflammatory activities may contribute to the pathogenesis of obesity-induced insulin resistance. Expand
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