Trans Fat Diet Induces Abdominal Obesity and Changes in Insulin Sensitivity in Monkeys

@article{Kavanagh2007TransFD,
  title={Trans Fat Diet Induces Abdominal Obesity and Changes in Insulin Sensitivity in Monkeys},
  author={K. Kavanagh and K. L. Jones and J. Sawyer and K. Kelley and J. Carr and J. D. Wagner and L. Rudel},
  journal={Obesity},
  year={2007},
  volume={15}
}
Objective: There is conflicting evidence about the propensity of trans fatty acids (TFAs) to cause obesity and insulin resistance. The effect of moderately high intake of dietary monounsaturated TFAs on body composition and indices of glucose metabolism was evaluated to determine any pro‐diabetic effect in the absence of weight gain. 
The Role of Dietary Fat in Insulin Resistance and Type 2 Diabetes
TLDR
Dietary fat has a role in both the etiology and prevention of insulin resistance and type 2 diabetes and the role of dietary fat is controversial as fatty acids act as signaling molecules in a variety of metabolic pathways. Expand
Trans fatty acids and weight gain
TLDR
There is limited but consistent evidence that increased TFA consumption may result in a small additional weight gain, and data from a primate model suggest that TFA may have a greater adipogenic effect than cis monounsaturated fatty acids. Expand
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TLDR
The associations of objectively measured plasma TFA concentrations with diabetes in a large population‐based study among US adults are examined. Expand
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TLDR
High TFA intake did not affect glucose metabolism over 16 weeks in postmenopausal overweight women, and a study population with a stronger predisposition to insulin resistance and/or a longer duration of exposure may be required for insulin sensitivity to be affected by intake of industrial TFA. Expand
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TLDR
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TLDR
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TLDR
It is concluded that lard-based high-fat diets accentuate the increase in weight gain and the development of obesity and insulin resistance more than hydrogenated vegetable-shortening diets. Expand
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TLDR
The evidence suggests that replacing saturated fats and trans fatty acids with unsaturated (polyunsaturated and/or monounsaturated) fats has beneficial effects on insulin sensitivity and is likely to reduce risk of type 2 diabetes. Expand
Effect of trans fatty acid intake on abdominal and liver fat deposition and blood lipids: a randomized trial in overweight postmenopausal women
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The adverse effect of dietary TFA on cardiovascular disease risk involves induction of dyslipidemia, and perhaps body fat, whereas weight gain-independent accumulation of ectopic fat could not be identified as a contributory factor during short-term intake. Expand
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