Trans Fat Diet Induces Abdominal Obesity and Changes in Insulin Sensitivity in Monkeys
@article{Kavanagh2007TransFD, title={Trans Fat Diet Induces Abdominal Obesity and Changes in Insulin Sensitivity in Monkeys}, author={Kylie Kavanagh and Kate L. Jones and Janet K. Sawyer and Kathryn L. Kelley and J. Jeffrey Carr and Janice D. Wagner and Lawrence L. Rudel}, journal={Obesity}, year={2007}, volume={15} }
Objective: There is conflicting evidence about the propensity of trans fatty acids (TFAs) to cause obesity and insulin resistance. The effect of moderately high intake of dietary monounsaturated TFAs on body composition and indices of glucose metabolism was evaluated to determine any pro‐diabetic effect in the absence of weight gain.
199 Citations
The Role of Dietary Fat in Insulin Resistance and Type 2 Diabetes
- Medicine
- 2010
Dietary fat has a role in both the etiology and prevention of insulin resistance and type 2 diabetes and the role of dietary fat is controversial as fatty acids act as signaling molecules in a variety of metabolic pathways.
Trans fatty acids and weight gain
- MedicineInternational Journal of Obesity
- 2011
There is limited but consistent evidence that increased TFA consumption may result in a small additional weight gain, and data from a primate model suggest that TFA may have a greater adipogenic effect than cis monounsaturated fatty acids.
Trans fatty acids, insulin resistance and diabetes
- Medicine, BiologyEuropean Journal of Clinical Nutrition
- 2011
It is concluded that there is limited evidence for a weak association at high TFA intakes, but very little convincing evidence that habitual exposure as part of a standard western diet has a significant contribution to risk of diabetes or insulin resistance.
Association between plasma trans‐fatty acid concentrations and diabetes in a nationally representative sample of US adults
- Medicine, BiologyJournal of diabetes
- 2018
The associations of objectively measured plasma TFA concentrations with diabetes in a large population‐based study among US adults are examined.
Effect of trans-fatty acid intake on insulin sensitivity and intramuscular lipids--a randomized trial in overweight postmenopausal women.
- MedicineMetabolism: clinical and experimental
- 2011
Regulators of Mitochondrial Quality Control Differs in Subcutaneous Fat of Metabolically Healthy and Unhealthy Obese Monkeys
- Medicine, BiologyObesity
- 2017
This study aimed to document the first spontaneous animal model of MHO and MUO and differences in SQ adipose tissue and underlying differences in the ability of subcutaneous fat to respond to nutrient excess.
A comparison of effects of lard and hydrogenated vegetable shortening on the development of high-fat diet-induced obesity in rats
- MedicineNutrition & Diabetes
- 2015
It is concluded that lard-based high-fat diets accentuate the increase in weight gain and the development of obesity and insulin resistance more than hydrogenated vegetable-shortening diets.
Effect of trans fatty acid intake on abdominal and liver fat deposition and blood lipids: a randomized trial in overweight postmenopausal women
- MedicineNutrition & Diabetes
- 2011
The adverse effect of dietary TFA on cardiovascular disease risk involves induction of dyslipidemia, and perhaps body fat, whereas weight gain-independent accumulation of ectopic fat could not be identified as a contributory factor during short-term intake.
References
SHOWING 1-10 OF 43 REFERENCES
High- versus low-fat diets in human diseases
- MedicineCurrent opinion in clinical nutrition and metabolic care
- 2003
A modest reduction in fat intake to 30-35% energy, with the bulk of carbohydrates being derived from complex carbohydrates from unrefined sources, would appear to be the best option for the prevention of obesity and cardiovascular disease.
Is insulin resistance influenced by dietary linoleic acid and trans fatty acids?
- MedicineFree radical biology & medicine
- 1994
Diet and risk of Type II diabetes: the role of types of fat and carbohydrate
- MedicineDiabetologia
- 2001
Dietary recommendations to prevent Type II diabetes should focus more on the quality of fat and carbohydrate in the diet than quantity alone, in addition to balancing total energy intake with expenditure to avoid overweight and obesity.
Obesity-induced inflammatory changes in adipose tissue.
- Biology, MedicineThe Journal of clinical investigation
- 2003
This issue of the JCI reports that obese adipose tissue is characterized by macrophage infiltration and that these macrophages are an important source of inflammation in this tissue.
A high-trans fatty acid diet and insulin sensitivity in young healthy women.
- MedicineMetabolism: clinical and experimental
- 1999
Intake of a Diet High in Trans Monounsaturated Fatty Acids or Saturated Fatty Acids: Effects on postprandial insulinemia and glycemia in obese patients with NIDDM
- MedicineDiabetes Care
- 1997
In the presence of unchanged glycemia, both dietary trans fatty acids and SFAs induce an increase in postprandial insulinemia in obese patients with NIDDM.
Comparison of the acute response to meals enriched with cis- or trans-fatty acids on glucose and lipids in overweight individuals with differing FABP2 genotypes.
- Medicine, BiologyMetabolism: clinical and experimental
- 2005
Effects of diets enriched in saturated (palmitic), monounsaturated (oleic), or trans (elaidic) fatty acids on insulin sensitivity and substrate oxidation in healthy adults.
- MedicineDiabetes care
- 2002
Dietary fatty acid composition significantly influenced fat oxidation but did not impact insulin sensitivity or secretion in lean individuals, and overweight individuals were more susceptible to developing insulin resistance on high-saturated fat diets.
Diet composition and the risk of type 2 diabetes: epidemiological and clinical evidence.
- MedicineThe British journal of nutrition
- 2004
New emphasis on prevention by multiple lifestyle modifications, including moderate changes in the composition of the habitual diet, might limit the dramatic increase in incidence of type 2 diabetes envisaged worldwide.
Chronic inflammation in fat plays a crucial role in the development of obesity-related insulin resistance.
- Biology, MedicineThe Journal of clinical investigation
- 2003
It is proposed that obesity-related insulin resistance is, at least in part, a chronic inflammatory disease initiated in adipose tissue, and that macrophage-related inflammatory activities may contribute to the pathogenesis of obesity-induced insulin resistance.