Trans-9-octadecenoic acid is biologically neutral and does not regulate the low density lipoprotein receptor as the cis isomer does in the hamster.

@article{Woollett1994Trans9octadecenoicAI,
  title={Trans-9-octadecenoic acid is biologically neutral and does not regulate the low density lipoprotein receptor as the cis isomer does in the hamster.},
  author={Laura A. Woollett and Chantal Daumerie and John M. Dietschy},
  journal={Journal of lipid research},
  year={1994},
  volume={35 9},
  pages={1661-73}
}
The concentration of cholesterol carried in low density lipoproteins (LDL-C) is primarily determined by the rate at which LDL-C is produced (Jt) and the rate at which the liver takes up this particle through receptor-dependent transport (Jm). The accumulation of specific dietary fatty acids in the liver profoundly alters these kinetic parameters and will either increase hepatic receptor activity or further suppress Jm, depending upon the particular fatty acid that enriches the various lipid… CONTINUE READING

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