Trans-10, cis-12 conjugated linoleic acid induced cell death in human colon cancer cells through reactive oxygen species-mediated ER stress.

@article{Pierre2013Trans10CC,
  title={Trans-10, cis-12 conjugated linoleic acid induced cell death in human colon cancer cells through reactive oxygen species-mediated ER stress.},
  author={A. Pierre and M{\'e}laine Minville-Walz and C{\'e}cile F{\`e}vre and Aziz Hichami and Joseph Gresti and Laurent Pichon and Sandrine Bellenger and J{\'e}r{\^o}me Bellenger and François Ghiringhelli and Michel Narce and Micka{\"e}l Rialland},
  journal={Biochimica et biophysica acta},
  year={2013},
  volume={1831 4},
  pages={759-68}
}
Dietary conjugated linoleic acids (CLA) are fatty acid isomers with anticancer activities produced naturally in ruminants or from vegetable oil processing. The anticancer effects of CLA differ upon the cancer origin and the CLA isomers. In this study, we carried out to precise the effects of CLA isomers, c9,t11 and t10,c12 CLA, on mechanisms of cell death induction in colon cancer cells. We first showed that only t10,c12 CLA treatment (25 and 50μM) for 72h triggered apoptosis in colon cancer… CONTINUE READING