Tranilast prevents atrial remodeling and development of atrial fibrillation in a canine model of atrial tachycardia and left ventricular dysfunction.

@article{Nakatani2013TranilastPA,
  title={Tranilast prevents atrial remodeling and development of atrial fibrillation in a canine model of atrial tachycardia and left ventricular dysfunction.},
  author={Yosuke Nakatani and Kunihiro Nishida and Masao Sakabe and Naoya Kataoka and Tamotsu Sakamoto and Yoshiaki Yamaguchi and Jotaro Iwamoto and Koichi Mizumaki and Akira Fujiki and Hiroshi Inoue},
  journal={Journal of the American College of Cardiology},
  year={2013},
  volume={61 5},
  pages={
          582-8
        }
}
OBJECTIVES This study sought to assess the effects of tranilast on atrial remodeling in a canine atrial fibrillation (AF) model. BACKGROUND Tranilast inhibits transforming growth factor (TGF)-β1 and prevents fibrosis in many pathophysiological settings. However, the effects of tranilast on atrial remodeling remain unclear. METHODS Beagles were subjected to atrial tachypacing (400 beats/min) for 4 weeks while treated with placebo (control dogs, n = 8) or tranilast (tranilast dogs, n = 10… CONTINUE READING
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